The effect of composition (gum Arabic (GA), maltodextrin (MD), surfactants, pH) and processing parameters (pressure and number of cycles of microfluidization) of α-tocopherol (AT) emulsions was studied via a coupled Taguchi-RMS optimization. Creaming index (CI), particle size (PS) and zeta potential (ζ) were selected as response variables. The estimated optimal conditions were found at GA of 40%, MD/surfactant mixture of 60%, 30% AT, pH of 4.9, P of 76 MPa and five cycles of microfluidization for a predicted CI of 0.5 % at 24 h with a PS of 384 nm. Under these conditions the experimental results were a 437 nm and 0.5 CI. It was possible to minimize the CI by varying the concentration of GA and modifying processing conditions.