This work reports, for the first time, the use of coffee pulp residue to the expression of cellulolytic and xylanolytic enzymes by the native fungus Penicillium citrinum CGETCR by solid-state fermentation (SSF). Coffee is one of the most important drinks in the world producing several residues such as coffee pulp, which is considered a contaminant if not properly disposed. This residue cause damage to the fauna from rivers due to its composition including tannins, pH 3.5, (1-4%) caffeine, polyphenolic compound, ochratoxin A, the presence of the latter three have toxic or nephrotoxic effects on higher animals. For these reasons, a study on the use of these residues to obtain high-added value products as enzymes of biotechnological interest, was performed. The enzyme production was optimized using the response surface methodology in a composite central design to study pH, moisture and fermentation time using endoglucanase activity as the response variable. The enzymatic activities found were β-glucosidases, endoglucanases, exoglucanases and xylanases which were able to function under acidic (4.0-5.5) and basic (7.5-8.0) conditions. Additionally, protein extract was used on agroindustrial residues as substrate to evaluate reducing sugar production.