PHOTODEGRADATION OF OMEPRAZOLE IN AQUEOUS SOLUTION USING TiO2 AS CATALYST
Keywords:
omeprazole, medicaments, photodegradation, titanium dioxide (TiO2)
Abstract
In this paper we have studied the photodegradation of omeprazole in aqueous solution, this medicament is the active ingredient in many antacids widely used worldwide. Omeprazole used in the experiments of degradation was obtained by the process of solid-liquid extraction from a generic brand commercial medicament. The degradation experiments were carried out in a reactor illuminated with low energy UV light lamps using TiO2 Degussa P25 as catalyst. The experimental results indicate that the organic compound is easily degraded in a very short period of time. However, the omeprazole molecule is not mineralized in a rapid manner. In the same way as other aromatic compounds, omeprazole is transformed to other organic compounds before being mineralized to CO2 and water.
References
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Anca F. C., Gavrilescu M. (2009). Pharmaceuticals, personal care products and endocrine disrupting agents in the environment- A Review. Clean Journal 37, 277-303.
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Boreen L. A., Arnold A. W., McNeill K. (2003). Photodegradation of pharmaceuticals in the aquatic environment: A review. Aquatic Sciences 65, 320-341.
Cantú Cárdenas L. G. (2008). Estudio de interacciones in vitro entre omeprazol y diferentes antiácidos. Revista de Salud Pública y Nutrición. Edición especial No. 13-2008, memorias del X congreso regional QFB.
Organizado por la FCQ de UANL del 8 al 11 de abril del 2008, San Nicolás de los Garzas N.L. México.
Caviglioli G., Valeria P., Brunella P., Sergio C., Attilia A., Gaetano B. (2002). Identification of products of iboprufen arising from oxidative and thermal treatments. Journal of Pharmaceutical and Biomedical Analysis 30, 499-509.
Contreras B. R., García A. R., Sandoval R. G., Burguen˜o V. G., Garc´ıa H. A., Moctezuma E., Perea C. D. (2009). Degradacio´n fotocatalítica de azul de metileno en aguas residuales utilizando TiO2 como catalizador. Revista Latinoamericana de Recursos Naturales 5, 86-91.
Cooper J. (1980). Spectroscopic Techniques for Organic Chemistry. Edit. John Wiley & sons. USA. Dalrymple O. K., Yeh D. H., Trotz M. A. (2007). Removing pharmaceuticals and endocrine discrupting compounds from wastewater by photocatalysis. Journal of Chemical Technology and Biotechnology 82, 121-134.
Daughton C. G. (2003). Cradle-to-Cradle Stewarship of Drugs for Minimizing Their Environmental Disposition While Promoting Human Health. Environmental Health Perspectives 111, 757-776.
Daughton C. G. (2005). “Emerging” Chemicals as Pollutants in the Environment a 21st Century Perspective. Renewable Resources Journal 24,6-23.
De Lasa, H., Serrano, B., Salaices, M. (2005). Photocatalytic Reaction Engineering, Springer, New York, USA.
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DellaGreca M., Iesce M.R., Previtera L., Rubino M., Temussi F., Brigante M. (2006). Degradation of lansoprazole and omeprazole in the aquatic environment. Chemosphere 63, 1087-1093
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Fujishima, Ak.,Rao, T.N., Tryk, D., A. (2000). Titanium dioxide photocatalysis. Journal of Photochemistry and Photobiology C 1, 1-21.
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Ge M., Li J. W., Liu L., Zhou Z. (2011). Template free synthesis and photocatalytic application of rutile TiO2 hierarchical nanostructures. Industrial and Engineering Chemistry Research 50, 6681- 6687.
Gennaro R. A. (2003). Remington Farmacia, 20a edición, tomo 2, pp. 1440. Editorial medica panamericana., Buenos Aires, Argentina.
Henschel K. P., Wenzel A., Diedrich M., Fliedner A. (1997). Environmental hazard assessment of pharmaceuticals. Regulatory Toxicology and Pharmacology 25, 220-225.
Lambert J., Shurvell H., Lightner D. (1998).Organic Structural Spectroscopy. Prentice Hall. USA. Leyva E., Montalvo C., Moctezuma E., Leyva S. (2008). Photocatalytic degradation of pyridine in water solution using ZnO as an alternative catalyst to TiO2. Journal of Ceramic Processing Research 9, 455-462.
Li X., Cubbage J. W., Jenks W. S. (1999a). Photocatalytic degradation of 4-chlorophenol. 1. The hydroquinone pathway. Journal of Organic Chemistry 64, 8509-8524.
Li X., Cubbage J. W., Jenks W. S. (1999b). Photocatalytic degradation of 4-chlorophenol. 2. The 4-chlorocatechol pathway. Journal of Organic Chemistry 64, 8525-8536.
Moctezuma E., Leyva E., Ruiz M. G., Torres M. L. (1998). Photodegradation of phenol and 4-clorophenol by BaO-LiO2-TiO2 catalysts. Catalysis Today 40, 367-376.
Moctezuma E., Leyva, E., Zamarripa, H. (2003). Degradación fotocatalítica de soluciones de Paraquat de alta concentración. Revista Internacional de Contaminación Ambiental 19, 115-123.
Moctezuma E., González, R., Zamarripa, H., Palestino, G., Oros, S. (2006). Kinetic studies of the photocatalytic degradation of the herbicide “Paraquat”. Journal of Environmental Management 16, 343-349.
Moctezuma E., Leyva E., Palestino G., De Lasa H. (2007). Photocatalytic degradation of methyl parathion: Reaction pathways and intermediate reaction products. Journal of Photochemistry and Photobiology A: Chemistry 186, 71-84.
Moctezuma E., Zermeño B., Zarazua E., Torres- Martínez L., García R. (2011). Photocatalytic degradation of phenol with Fe-titania catalyst. Topics in Catalysis 54, 496-503.
Moctezuma E., Leyva E., Aguilar C., Luna R., Montalvo C. (2012). Photocatalytic degradation of paracetamol: Intermediates and total reaction mechanism. Journal of Hazardous Materials 243, 130-138.
Molinari R., Prillo F., Loddo V., Palmisano L. (2006). Heterogeneus photocatalytic degradation of pharmaceuticals in water by using polycrystalline TiO2 and a nanofiltration membrane reactor. Catalysis Today 118, 205-213.
Ortiz G. A., Serrano R. B., Salaices M., De Lasa H. (2007). Photocatalytic oxidation of phenol: reaction network, kinetic modeling and parameter estimation. Industrial and Engineering Chemistry Research 46, 7394-7409.
Pavia, Lampman, Kriz. (2001). Introduction to Spectroscopy.3ra edición, Harcourt. USA.
Pérez L. A., Maldonado M. I., Gerjank W., Agu¨era A. (2005). Decomposition of diclofenac by solar driven photocatalysis at pilot plant scale. Catalysis Today 101, 219-222.
Ribani M., Collins C. H., Bottoli C. B. G. (2007). Validation of chromatographic methods: Evaluation of detection and quantification limits in the determination of impurities in omeprazole. Journal of Chromatography A
1156, 201-205. Sigma Aldrich (2008). Disponible en: http://www.sigmaaldrich.com/catalog/Product Detail.do?lang=es&N4=O104—SIGMA &N5=SEARCH CONCAT PNO—BRAND KEY&F=SPEC
Thomas K., Dye C., Schalabanch M., Langford K. (2007). Source to sink tracking of selected human pharmaceuticals from two Oslo city hospitals and wastewater treatment work. Journal of Environmental Monitoring 9, 1410-1418.
Zermeño B., Moctezuma E., García-Alamilla R. (2011). Photocatalytic degradation of phenol and 4-clorophenol with titania, oxygen and ozone. Sustainable Environment Research 21, 299-305.
Zou L., Zhu B. (2008). The effect of ozonation and photocatalysis on color removal from reused water. Journal of Photochemistry and Photobiology A: Chemistry 196, 24-32
Anca F. C., Gavrilescu M. (2009). Pharmaceuticals, personal care products and endocrine disrupting agents in the environment- A Review. Clean Journal 37, 277-303.
Andreozzi R., Caprio V., Insola A., Marotta R. (1999). Advanced oxidation processes (AOP) for water purification and recovery. Catalysis Today 53, 51-59.
Andreozzi R., Raffaele M., Nicklas P. (2003). Pharmaceuticals in STP effluents and their solar photodegradation in aquatic environment. Chemosphere 50, 1319-1330.
Braum A., Lengrini O., Oliveros E. (1993). Photochemical processes for water treatment. Chemical Reviews 93, 671-698.
Boreen L. A., Arnold A. W., McNeill K. (2003). Photodegradation of pharmaceuticals in the aquatic environment: A review. Aquatic Sciences 65, 320-341.
Cantú Cárdenas L. G. (2008). Estudio de interacciones in vitro entre omeprazol y diferentes antiácidos. Revista de Salud Pública y Nutrición. Edición especial No. 13-2008, memorias del X congreso regional QFB.
Organizado por la FCQ de UANL del 8 al 11 de abril del 2008, San Nicolás de los Garzas N.L. México.
Caviglioli G., Valeria P., Brunella P., Sergio C., Attilia A., Gaetano B. (2002). Identification of products of iboprufen arising from oxidative and thermal treatments. Journal of Pharmaceutical and Biomedical Analysis 30, 499-509.
Contreras B. R., García A. R., Sandoval R. G., Burguen˜o V. G., Garc´ıa H. A., Moctezuma E., Perea C. D. (2009). Degradacio´n fotocatalítica de azul de metileno en aguas residuales utilizando TiO2 como catalizador. Revista Latinoamericana de Recursos Naturales 5, 86-91.
Cooper J. (1980). Spectroscopic Techniques for Organic Chemistry. Edit. John Wiley & sons. USA. Dalrymple O. K., Yeh D. H., Trotz M. A. (2007). Removing pharmaceuticals and endocrine discrupting compounds from wastewater by photocatalysis. Journal of Chemical Technology and Biotechnology 82, 121-134.
Daughton C. G. (2003). Cradle-to-Cradle Stewarship of Drugs for Minimizing Their Environmental Disposition While Promoting Human Health. Environmental Health Perspectives 111, 757-776.
Daughton C. G. (2005). “Emerging” Chemicals as Pollutants in the Environment a 21st Century Perspective. Renewable Resources Journal 24,6-23.
De Lasa, H., Serrano, B., Salaices, M. (2005). Photocatalytic Reaction Engineering, Springer, New York, USA.
Delgado J. M. (2009). Alertan por consumo indiscriminado del Omeprazol., Escuela de química y farmacia de la Universidad Andrés Bello., edición Universia, Universidad Andrés Bello. Disponible en: http://noticias.universia.cl/vida universitaria/noticia/2009/09/09/277530/alertan consumo-indiscriminado- omeprazol.pdf
DellaGreca M., Iesce M.R., Previtera L., Rubino M., Temussi F., Brigante M. (2006). Degradation of lansoprazole and omeprazole in the aquatic environment. Chemosphere 63, 1087-1093
Doménech, X., Litter, M., Mansilla, H. (2004). Procesos avanzados de oxidación para la eliminación de contaminantes, Blesa, M.A., Sánchez, B., editores. Eliminación de Contaminantes por Fotocatalísis Heterogénea,
Editorial CIEMAT, 2004.
Ficha técnica del medicamento omeprazol. (2008). Ministro de sanidad, política social e igualdad. Agencia española de medicamentos y productos sanitarios. Disponible en: http://www.gesgenericos.com/productos
pdf/600258-2.pdf
Fujishima, Ak.,Rao, T.N., Tryk, D., A. (2000). Titanium dioxide photocatalysis. Journal of Photochemistry and Photobiology C 1, 1-21.
Galindo G. R. (2009). Síntesis de catalizadores de plata soportados en TiO2, ZrO2 y ZnO, para su aplicación en el control de la contaminación ambiental. Tesis de maestría, CIEP/FCQ, UASLP, México.
Ge M., Li J. W., Liu L., Zhou Z. (2011). Template free synthesis and photocatalytic application of rutile TiO2 hierarchical nanostructures. Industrial and Engineering Chemistry Research 50, 6681- 6687.
Gennaro R. A. (2003). Remington Farmacia, 20a edición, tomo 2, pp. 1440. Editorial medica panamericana., Buenos Aires, Argentina.
Henschel K. P., Wenzel A., Diedrich M., Fliedner A. (1997). Environmental hazard assessment of pharmaceuticals. Regulatory Toxicology and Pharmacology 25, 220-225.
Lambert J., Shurvell H., Lightner D. (1998).Organic Structural Spectroscopy. Prentice Hall. USA. Leyva E., Montalvo C., Moctezuma E., Leyva S. (2008). Photocatalytic degradation of pyridine in water solution using ZnO as an alternative catalyst to TiO2. Journal of Ceramic Processing Research 9, 455-462.
Li X., Cubbage J. W., Jenks W. S. (1999a). Photocatalytic degradation of 4-chlorophenol. 1. The hydroquinone pathway. Journal of Organic Chemistry 64, 8509-8524.
Li X., Cubbage J. W., Jenks W. S. (1999b). Photocatalytic degradation of 4-chlorophenol. 2. The 4-chlorocatechol pathway. Journal of Organic Chemistry 64, 8525-8536.
Moctezuma E., Leyva E., Ruiz M. G., Torres M. L. (1998). Photodegradation of phenol and 4-clorophenol by BaO-LiO2-TiO2 catalysts. Catalysis Today 40, 367-376.
Moctezuma E., Leyva, E., Zamarripa, H. (2003). Degradación fotocatalítica de soluciones de Paraquat de alta concentración. Revista Internacional de Contaminación Ambiental 19, 115-123.
Moctezuma E., González, R., Zamarripa, H., Palestino, G., Oros, S. (2006). Kinetic studies of the photocatalytic degradation of the herbicide “Paraquat”. Journal of Environmental Management 16, 343-349.
Moctezuma E., Leyva E., Palestino G., De Lasa H. (2007). Photocatalytic degradation of methyl parathion: Reaction pathways and intermediate reaction products. Journal of Photochemistry and Photobiology A: Chemistry 186, 71-84.
Moctezuma E., Zermeño B., Zarazua E., Torres- Martínez L., García R. (2011). Photocatalytic degradation of phenol with Fe-titania catalyst. Topics in Catalysis 54, 496-503.
Moctezuma E., Leyva E., Aguilar C., Luna R., Montalvo C. (2012). Photocatalytic degradation of paracetamol: Intermediates and total reaction mechanism. Journal of Hazardous Materials 243, 130-138.
Molinari R., Prillo F., Loddo V., Palmisano L. (2006). Heterogeneus photocatalytic degradation of pharmaceuticals in water by using polycrystalline TiO2 and a nanofiltration membrane reactor. Catalysis Today 118, 205-213.
Ortiz G. A., Serrano R. B., Salaices M., De Lasa H. (2007). Photocatalytic oxidation of phenol: reaction network, kinetic modeling and parameter estimation. Industrial and Engineering Chemistry Research 46, 7394-7409.
Pavia, Lampman, Kriz. (2001). Introduction to Spectroscopy.3ra edición, Harcourt. USA.
Pérez L. A., Maldonado M. I., Gerjank W., Agu¨era A. (2005). Decomposition of diclofenac by solar driven photocatalysis at pilot plant scale. Catalysis Today 101, 219-222.
Ribani M., Collins C. H., Bottoli C. B. G. (2007). Validation of chromatographic methods: Evaluation of detection and quantification limits in the determination of impurities in omeprazole. Journal of Chromatography A
1156, 201-205. Sigma Aldrich (2008). Disponible en: http://www.sigmaaldrich.com/catalog/Product Detail.do?lang=es&N4=O104—SIGMA &N5=SEARCH CONCAT PNO—BRAND KEY&F=SPEC
Thomas K., Dye C., Schalabanch M., Langford K. (2007). Source to sink tracking of selected human pharmaceuticals from two Oslo city hospitals and wastewater treatment work. Journal of Environmental Monitoring 9, 1410-1418.
Zermeño B., Moctezuma E., García-Alamilla R. (2011). Photocatalytic degradation of phenol and 4-clorophenol with titania, oxygen and ozone. Sustainable Environment Research 21, 299-305.
Zou L., Zhu B. (2008). The effect of ozonation and photocatalysis on color removal from reused water. Journal of Photochemistry and Photobiology A: Chemistry 196, 24-32
Published
2020-03-17
How to Cite
Luna-Sánchez, R., Zermeño-Resendiz, B., Moctezuma, E., Contreras-Bermúdez, R., Leyva, E., & López-Barragán, M. (2020). PHOTODEGRADATION OF OMEPRAZOLE IN AQUEOUS SOLUTION USING TiO2 AS CATALYST. Revista Mexicana De Ingeniería Química, 12(1), 85-95. Retrieved from http://rmiq.org/ojs311/index.php/rmiq/article/view/1459
Section
Catalysis, kinetics and reactors
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