Determination of interfacial energy of the system acetylsalicylic acid-ethanol using the 3D nucleation theory and the integral method

  • X.M. Medina-Galvan Departamento de Ingeniería Química del Instituto Tecnológico de México en Celaya
  • P.A. Quintana-Hernández
  • E.M. Escamilla-Silva
  • L.F. Fuentes-Cortés
Keywords: acetylsalicylic acid, anhydrous ethanol, crystallization, integral method, interfacial energy


In this work, the interfacial energy of the acetylsalicylic acid-ethanol system was evaluated using experimental results of the metastable zone width (MSZW) obtained at different operation conditions: agitation rate (230 and 400 rpm), cooing rate (6, 9 12 and 15 K/h) and saturation temperature (288.15, 293.15, 298.15, 303.15, 308.15 and 313.15 K). A nonlinear regression algorithm and a simple to implement lineal integration approach of the number density of nuclei were used to determine the interfacial energy. The results obtained with the two integral strategies were compared with the values obtained with the 3D nucleation theory. Estimations obtained with the nonlinear regression presented a difference smaller than 6.5 % but estimations determined with the lineal integration approach had an average difference of 48.6 %.


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How to Cite
Medina-Galvan, X., Quintana-Hernández, P., Escamilla-Silva, E., & Fuentes-Cortés, L. (2022). Determination of interfacial energy of the system acetylsalicylic acid-ethanol using the 3D nucleation theory and the integral method. Revista Mexicana De Ingeniería Química, 22(1), Proc2884.
Process engineering